Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.121


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_271626880.341.9e-01Click!
HOXB7chr17_-_440432780.087.6e-01Click!
HOXA6chr7_-_271538920.058.5e-01Click!
HOXB6chr17_-_440373320.019.7e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_41579325 13.442


chr7_-_96471544 12.170 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_105511615 10.580 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr8_-_114518194 10.355 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr1_-_214963279 8.097 NM_001438
ESRRG
estrogen-related receptor gamma
chr5_+_170668892 8.003 NM_021025
TLX3
T-cell leukemia homeobox 3
chr18_-_28606839 7.343 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr2_-_200033445 7.078 SATB2
SATB homeobox 2
chr14_+_75907442 6.998 NM_004452
ESRRB
estrogen-related receptor beta
chr1_-_188713324 6.793 NM_199051
FAM5C
family with sequence similarity 5, member C
chr10_+_83627422 6.649 NM_001165973
NRG3
neuregulin 3
chr13_-_45323757 6.531 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr13_-_101852028 6.205 NM_175929
FGF14
fibroblast growth factor 14
chr18_-_39111243 6.030 NM_020783
SYT4
synaptotagmin IV
chr14_-_94306104 5.864 NM_173849
GSC
goosecoid homeobox
chr12_+_79625538 5.766 NM_002469
MYF6
myogenic factor 6 (herculin)
chr10_+_68355797 5.705 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr12_-_14024187 5.681 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr12_-_23995220 5.552 SOX5
SRY (sex determining region Y)-box 5
chr16_-_49742651 5.506 NM_002968
SALL1
sal-like 1 (Drosophila)
chr12_-_16652202 5.438 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_61532293 5.432 NM_031914
SYT16
synaptotagmin XVI
chr11_-_16380967 5.346 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr1_+_61642287 5.333 NFIA
nuclear factor I/A
chr11_-_27679617 5.332 NM_170733
BDNF
brain-derived neurotrophic factor
chr12_-_23995109 5.304 SOX5
SRY (sex determining region Y)-box 5
chr11_-_27698800 5.240 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr4_-_110443247 5.204 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chrX_+_99726445 5.157 NM_022144
TNMD
tenomodulin
chr3_+_174598937 5.085 NM_014932
NLGN1
neuroligin 1
chr14_-_56346849 5.027 NM_021728
OTX2
orthodenticle homeobox 2
chr21_-_38955487 4.931 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr8_+_104900591 4.922 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr18_-_55136673 4.844 NM_181654
CPLX4
complexin 4
chr6_+_50894397 4.814 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chrX_+_28515479 4.767 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr2_+_171280182 4.673


chr3_+_35696119 4.638 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chrX_-_137649180 4.580 NM_033642
FGF13
fibroblast growth factor 13
chr3_-_62334229 4.574 NM_018008
FEZF2
FEZ family zinc finger 2
chr4_-_116254381 4.546 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr2_+_225973845 4.484 NM_020864
KIAA1486
KIAA1486
chr11_-_84311867 4.475 DLG2
discs, large homolog 2 (Drosophila)
chr5_-_76970129 4.409 OTP
orthopedia homeobox
chr9_-_8723893 4.355 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr2_+_171280046 4.304 NM_001003845
SP5
Sp5 transcription factor
chr2_+_234490781 4.282 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr13_-_83354474 4.272 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr5_-_76970264 4.221 NM_032109
OTP
orthopedia homeobox
chr11_-_123695302 4.188 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr7_+_28418668 4.144 NM_182898
CREB5
cAMP responsive element binding protein 5
chr5_-_95794416 4.006 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr6_-_101018271 3.990 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr4_-_41445693 3.957 NM_003924
PHOX2B
paired-like homeobox 2b
chr13_-_34948758 3.903 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr3_-_79899748 3.899 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr13_-_83354425 3.887 SLITRK1
SLIT and NTRK-like family, member 1
chr4_+_174688183 3.881 NBLA00301
Nbla00301
chr12_+_84198015 3.861 NM_006982
ALX1
ALX homeobox 1
chr12_+_106692291 3.833 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr11_+_113280727 3.778 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr10_+_118073929 3.748 NM_198515
C10orf96
chromosome 10 open reading frame 96
chr4_-_187114407 3.707 SORBS2
sorbin and SH3 domain containing 2
chr6_+_108593907 3.690 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr4_-_174687931 3.678 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr3_-_55489973 3.674 WNT5A
wingless-type MMTV integration site family, member 5A
chr17_-_44047299 3.656 NM_024016
HOXB8
homeobox B8
chr8_+_65655367 3.651 NM_152414
BHLHE22
basic helix-loop-helix family, member e22
chr1_+_81544432 3.640 LPHN2
latrophilin 2
chr20_-_49852353 3.590 NM_020436
SALL4
sal-like 4 (Drosophila)
chr15_+_46285789 3.578 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr7_+_94377145 3.539 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr7_-_27133163 3.530 NM_153631
HOXA3
homeobox A3
chr15_+_46271158 3.489 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr13_+_34948977 3.444 NBEA
neurobeachin
chr8_+_24354387 3.429 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr12_+_63510481 3.413


chr7_+_18296569 3.379 HDAC9
histone deacetylase 9
chr6_+_50789215 3.377 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr3_+_35697432 3.358 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_+_89239494 3.339 EPHA3
EPH receptor A3
chr6_+_100161370 3.325 NM_021620
PRDM13
PR domain containing 13
chr4_-_21308415 3.323 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr8_-_72431274 3.309 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr13_+_34948885 3.308 NBEA
neurobeachin
chr14_-_60185659 3.290 NM_005982
SIX1
SIX homeobox 1
chr4_-_20914626 3.266 NM_147183
KCNIP4
Kv channel interacting protein 4
chr1_+_50348052 3.244 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_-_99236520 3.212 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr3_+_129124591 3.209 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_-_115380539 3.183 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr1_+_50344550 3.155 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr10_-_118887801 3.126 NM_001112704
NM_199131
VAX1

ventral anterior homeobox 1

chr4_-_41445479 3.117 PHOX2B
paired-like homeobox 2b
chr2_+_214984705 3.111 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr3_+_149930656 3.037 NM_032049
AGTR1
angiotensin II receptor, type 1
chr4_+_41309690 3.023 LIMCH1
LIM and calponin homology domains 1
chr12_-_23993830 3.008 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr5_-_41546384 2.997 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chrX_-_33267646 2.975 NM_000109
DMD
dystrophin
chr3_+_2528272 2.955 CNTN4
contactin 4
chr11_-_84312085 2.948 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_50347176 2.901 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr8_-_93176819 2.892 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_56342097 2.888 NM_172337
OTX2
orthodenticle homeobox 2
chr4_-_184480572 2.879 NM_001185149
CLDN24
claudin 24
chr1_+_50342168 2.871 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_65503011 2.866 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr5_-_22248630 2.865 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr18_-_29882555 2.857 NM_001198549
NOL4
nucleolar protein 4
chr4_+_41309482 2.846 LIMCH1
LIM and calponin homology domains 1
chrX_-_32340291 2.845 NM_004011
NM_004012
DMD

dystrophin

chr11_-_36576352 2.818 NM_000536
RAG2
recombination activating gene 2
chr11_+_22316242 2.808 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr17_+_72047709 2.788 NM_001077620
PRCD
progressive rod-cone degeneration
chr18_+_57308754 2.778 NM_031891
CDH20
cadherin 20, type 2
chr11_-_27679175 2.771 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr4_+_41309668 2.751 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_175406685 2.736 FAM5B
family with sequence similarity 5, member B
chr6_-_94185780 2.727 NM_004440
EPHA7
EPH receptor A7
chr4_-_20594645 2.724 KCNIP4
Kv channel interacting protein 4
chr15_+_56217686 2.719 NM_020980
AQP9
aquaporin 9
chr3_-_57209319 2.708 NM_003865
HESX1
HESX homeobox 1
chr18_-_3864252 2.698 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr3_+_35658852 2.687 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr13_-_52320774 2.668 NM_002590
NM_032949
PCDH8

protocadherin 8

chrX_+_11221453 2.668 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr8_-_93176618 2.666 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr7_-_31347032 2.661 NM_022728
NEUROD6
neurogenic differentiation 6
chr12_-_16649211 2.648 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_187114863 2.642 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr18_+_30427279 2.636 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr5_-_88004891 2.622 LOC645323
hypothetical LOC645323
chr3_+_68136056 2.605 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr7_+_113842284 2.605 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_+_168898898 2.590 PRRX1
paired related homeobox 1
chr7_-_19151509 2.574 NM_152898
FERD3L
Fer3-like (Drosophila)
chr11_-_30558495 2.571 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr12_-_16321885 2.557 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr1_-_93030538 2.549 NM_005665
EVI5
ecotropic viral integration site 5
chr11_-_27700180 2.539 NM_170731
BDNF
brain-derived neurotrophic factor
chrX_+_135558001 2.528 NM_000074
CD40LG
CD40 ligand
chr1_+_50347188 2.519 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_58918031 2.518 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_83116414 2.500 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr9_-_72673753 2.500 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr14_-_80934523 2.477 NM_033104
STON2
stonin 2
chr2_+_211166323 2.475 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_-_195302973 2.464 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr1_+_198263352 2.458 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr7_+_113842470 2.457 FOXP2
forkhead box P2
chr3_+_1109619 2.456 NM_014461
CNTN6
contactin 6
chr4_+_119174947 2.437 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr4_+_114190233 2.423 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr7_+_18501876 2.417 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr3_-_139333813 2.414 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr3_+_116824840 2.410 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr2_+_137464931 2.408 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr4_-_44348414 2.403 NM_182592
YIPF7
Yip1 domain family, member 7
chr12_-_10846435 2.383 NM_023919
TAS2R7
taste receptor, type 2, member 7
chrX_+_82649924 2.382 NM_000307
POU3F4
POU class 3 homeobox 4
chr12_+_40117751 2.345 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr7_+_113842407 2.339 FOXP2
forkhead box P2
chr14_-_57030227 2.332 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr8_-_91164100 2.290 NM_004929
CALB1
calbindin 1, 28kDa
chrX_+_9391314 2.283 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr12_+_84792203 2.275 NM_006183
NTS
neurotensin
chr18_+_53170718 2.274 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr11_-_26700121 2.272 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr18_+_50409387 2.260 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr1_-_163680941 2.259 NM_006917
RXRG
retinoid X receptor, gamma
chr2_-_183095308 2.257 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr3_-_71262426 2.236 FOXP1
forkhead box P1
chr18_-_68683913 2.231 NM_138999
NM_153181
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chr5_-_1935764 2.228 NM_016358
IRX4
iroquois homeobox 4
chr7_-_36992221 2.211 NM_130442
ELMO1
engulfment and cell motility 1
chr4_+_41395493 2.206 LIMCH1
LIM and calponin homology domains 1
chr5_-_145232723 2.178 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr13_+_77213295 2.173 NM_144595
SLAIN1
SLAIN motif family, member 1
chr12_+_79362256 2.170 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr2_-_182253457 2.160 NM_002500
NEUROD1
neurogenic differentiation 1
chr17_-_30909219 2.142 NM_001129820
SLFN14
schlafen family member 14
chr3_-_54937001 2.127 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr12_-_98072602 2.124 NM_020140
NM_181670
ANKS1B

ankyrin repeat and sterile alpha motif domain containing 1B

chr6_-_64087806 2.111 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr18_-_30057512 2.106 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr4_+_93444572 2.095 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr17_-_36403910 2.086 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr14_-_100105883 2.083 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr12_-_16650697 2.069 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_31782169 2.062 PAX6
paired box 6
chr5_-_134899537 2.059 NM_006161
NEUROG1
neurogenin 1
chr3_+_171560104 2.058 NM_001145097
SKIL
SKI-like oncogene
chr7_-_5429702 2.031 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr18_+_74841262 2.023 NM_171999
SALL3
sal-like 3 (Drosophila)
chr7_-_72676750 2.019 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr5_+_166644420 2.017 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr9_+_27099138 2.016 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr12_+_52697160 2.013 HOXC5
HOXC6
homeobox C5
homeobox C6
chr12_-_16650687 2.010 LMO3
LIM domain only 3 (rhombotin-like 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 4.41e-45 GO:0032501 multicellular organismal process
1.41 4.32e-29 GO:0007275 multicellular organismal development
1.38 1.45e-27 GO:0032502 developmental process
1.45 2.20e-27 GO:0048731 system development
1.41 2.55e-25 GO:0048856 anatomical structure development
1.64 2.73e-25 GO:0007399 nervous system development
1.49 4.45e-17 GO:0003008 system process
1.66 1.85e-15 GO:0022008 neurogenesis
1.42 2.46e-15 GO:0030154 cell differentiation
1.67 9.59e-15 GO:0048699 generation of neurons
1.40 4.50e-14 GO:0048869 cellular developmental process
1.50 9.23e-14 GO:0050877 neurological system process
1.40 1.02e-12 GO:0048513 organ development
1.18 3.09e-12 GO:0050896 response to stimulus
1.67 5.51e-11 GO:0045595 regulation of cell differentiation
1.65 7.87e-11 GO:0030182 neuron differentiation
1.42 2.24e-10 GO:0009653 anatomical structure morphogenesis
1.53 1.29e-09 GO:0050793 regulation of developmental process
1.59 1.50e-09 GO:2000026 regulation of multicellular organismal development
1.92 2.66e-09 GO:0060284 regulation of cell development
1.72 3.36e-09 GO:0007417 central nervous system development
1.98 3.66e-09 GO:0051960 regulation of nervous system development
1.55 4.14e-09 GO:0007600 sensory perception
1.58 4.77e-09 GO:0010557 positive regulation of macromolecule biosynthetic process
1.49 1.31e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.01 2.36e-08 GO:0050767 regulation of neurogenesis
1.61 3.60e-08 GO:0045893 positive regulation of transcription, DNA-dependent
1.50 1.15e-07 GO:0009891 positive regulation of biosynthetic process
1.12 1.47e-07 GO:0065007 biological regulation
1.57 1.79e-07 GO:0010628 positive regulation of gene expression
1.56 1.91e-07 GO:0009790 embryo development
1.68 2.23e-07 GO:0007606 sensory perception of chemical stimulus
1.60 2.36e-07 GO:0009887 organ morphogenesis
1.70 2.94e-07 GO:0032583 regulation of gene-specific transcription
1.50 3.44e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.46 6.30e-07 GO:0048468 cell development
1.46 2.59e-06 GO:0009888 tissue development
1.67 2.60e-06 GO:0007608 sensory perception of smell
1.99 2.72e-06 GO:0045664 regulation of neuron differentiation
1.63 3.11e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.16 3.56e-06 GO:0045165 cell fate commitment
1.12 4.89e-06 GO:0050789 regulation of biological process
1.52 5.17e-06 GO:0051254 positive regulation of RNA metabolic process
1.89 5.86e-06 GO:0003002 regionalization
1.13 6.11e-06 GO:0050794 regulation of cellular process
1.46 1.61e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.47 1.70e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 2.09e-05 GO:0051239 regulation of multicellular organismal process
3.07 2.83e-05 GO:0048663 neuron fate commitment
1.24 3.00e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.22 4.35e-05 GO:0048518 positive regulation of biological process
1.25 4.48e-05 GO:0006355 regulation of transcription, DNA-dependent
2.49 4.80e-05 GO:0021953 central nervous system neuron differentiation
1.69 4.87e-05 GO:0007389 pattern specification process
1.26 5.10e-05 GO:0048523 negative regulation of cellular process
1.24 5.22e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.60 5.58e-05 GO:0051094 positive regulation of developmental process
1.66 6.06e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.10 7.59e-05 GO:0007156 homophilic cell adhesion
1.92 7.84e-05 GO:0048732 gland development
1.56 8.85e-05 GO:0000904 cell morphogenesis involved in differentiation
1.51 1.45e-04 GO:0048666 neuron development
1.24 1.74e-04 GO:0051252 regulation of RNA metabolic process
1.76 1.89e-04 GO:0045596 negative regulation of cell differentiation
1.67 2.04e-04 GO:0045597 positive regulation of cell differentiation
1.63 2.90e-04 GO:0007420 brain development
1.60 3.81e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.21 4.91e-04 GO:0009889 regulation of biosynthetic process
1.22 5.77e-04 GO:0048522 positive regulation of cellular process
1.39 5.88e-04 GO:0006351 transcription, DNA-dependent
1.33 6.35e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.21 6.99e-04 GO:0010468 regulation of gene expression
1.22 8.31e-04 GO:0048519 negative regulation of biological process
1.18 8.71e-04 GO:0060255 regulation of macromolecule metabolic process
1.20 9.60e-04 GO:0031326 regulation of cellular biosynthetic process
1.31 1.24e-03 GO:0009893 positive regulation of metabolic process
1.46 1.26e-03 GO:0000902 cell morphogenesis
1.16 1.29e-03 GO:0023052 signaling
1.32 1.32e-03 GO:0031325 positive regulation of cellular metabolic process
2.30 1.47e-03 GO:0048706 embryonic skeletal system development
1.92 1.59e-03 GO:0048562 embryonic organ morphogenesis
1.20 1.68e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 1.77e-03 GO:0045892 negative regulation of transcription, DNA-dependent
3.82 1.83e-03 GO:0048665 neuron fate specification
1.54 2.63e-03 GO:0007409 axonogenesis
1.49 2.66e-03 GO:0031175 neuron projection development
1.66 2.77e-03 GO:0061061 muscle structure development
4.72 2.78e-03 GO:0048713 regulation of oligodendrocyte differentiation
1.56 3.23e-03 GO:0009792 embryo development ending in birth or egg hatching
1.52 3.25e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 3.29e-03 GO:0048598 embryonic morphogenesis
1.46 3.65e-03 GO:0051253 negative regulation of RNA metabolic process
2.05 3.71e-03 GO:0043583 ear development
1.51 4.77e-03 GO:0048812 neuron projection morphogenesis
1.82 5.06e-03 GO:0030900 forebrain development
1.60 5.31e-03 GO:0001501 skeletal system development
1.33 5.66e-03 GO:0032774 RNA biosynthetic process
1.55 6.09e-03 GO:0043009 chordate embryonic development
1.59 6.16e-03 GO:0051093 negative regulation of developmental process
1.70 6.31e-03 GO:0048568 embryonic organ development
1.35 6.64e-03 GO:0040011 locomotion
1.72 8.52e-03 GO:0043193 positive regulation of gene-specific transcription
1.18 8.63e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.86 8.98e-03 GO:0043062 extracellular structure organization
1.41 9.12e-03 GO:0032989 cellular component morphogenesis
1.21 9.96e-03 GO:0065008 regulation of biological quality
1.16 1.06e-02 GO:0080090 regulation of primary metabolic process
2.81 1.11e-02 GO:0001708 cell fate specification
1.41 1.24e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82 1.27e-02 GO:0009952 anterior/posterior pattern formation
2.34 1.36e-02 GO:0007519 skeletal muscle tissue development
1.58 1.44e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.36 1.50e-02 GO:0007155 cell adhesion
1.36 1.50e-02 GO:0022610 biological adhesion
1.85 1.60e-02 GO:0001655 urogenital system development
1.89 1.66e-02 GO:0060537 muscle tissue development
1.31 1.67e-02 GO:0009605 response to external stimulus
2.28 1.79e-02 GO:0060538 skeletal muscle organ development
2.54 1.91e-02 GO:0021510 spinal cord development
1.44 2.29e-02 GO:0032990 cell part morphogenesis
1.44 2.37e-02 GO:0048858 cell projection morphogenesis
1.40 2.41e-02 GO:0010629 negative regulation of gene expression
2.05 2.60e-02 GO:0048839 inner ear development
1.40 2.64e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
2.94 2.69e-02 GO:0021515 cell differentiation in spinal cord
2.74 3.16e-02 GO:0021536 diencephalon development
1.54 3.31e-02 GO:0007411 axon guidance
1.38 3.38e-02 GO:0030030 cell projection organization
1.15 3.84e-02 GO:0007165 signal transduction
1.39 4.00e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.58 4.12e-02 GO:0035295 tube development
2.97 4.38e-02 GO:0045685 regulation of glial cell differentiation
2.16 4.53e-02 GO:0022612 gland morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 9.02e-16 GO:0005886 plasma membrane
1.25 8.25e-15 GO:0071944 cell periphery
1.38 5.34e-06 GO:0044421 extracellular region part
1.26 6.91e-06 GO:0005576 extracellular region
1.24 1.27e-05 GO:0044459 plasma membrane part
1.37 4.07e-04 GO:0005615 extracellular space
1.53 5.60e-04 GO:0043005 neuron projection
2.33 4.85e-03 GO:0031091 platelet alpha granule
1.10 5.56e-03 GO:0044425 membrane part
2.40 5.80e-03 GO:0031983 vesicle lumen
1.38 7.05e-03 GO:0030054 cell junction
1.31 7.51e-03 GO:0042995 cell projection
2.43 1.02e-02 GO:0031093 platelet alpha granule lumen
1.08 1.21e-02 GO:0016020 membrane
1.45 1.30e-02 GO:0045202 synapse
1.46 1.37e-02 GO:0009986 cell surface
2.38 1.55e-02 GO:0034774 secretory granule lumen
1.45 2.11e-02 GO:0031012 extracellular matrix
2.28 3.36e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.64 3.49e-02 GO:0030424 axon

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.87 1.38e-21 GO:0043565 sequence-specific DNA binding
1.68 9.09e-20 GO:0001071 nucleic acid binding transcription factor activity
1.68 9.09e-20 GO:0003700 sequence-specific DNA binding transcription factor activity
1.58 1.83e-14 GO:0030528 transcription regulator activity
1.37 6.37e-10 GO:0004872 receptor activity
1.40 2.08e-08 GO:0004888 transmembrane receptor activity
1.30 3.41e-08 GO:0004871 signal transducer activity
1.30 3.41e-08 GO:0060089 molecular transducer activity
1.71 1.97e-07 GO:0004984 olfactory receptor activity
1.46 4.34e-07 GO:0004930 G-protein coupled receptor activity
1.46 4.32e-05 GO:0005509 calcium ion binding
1.82 8.15e-05 GO:0000975 regulatory region DNA binding
1.82 8.15e-05 GO:0001067 regulatory region nucleic acid binding
1.82 8.15e-05 GO:0044212 transcription regulatory region DNA binding
1.82 1.71e-04 GO:0010843 promoter binding
1.32 7.75e-04 GO:0005102 receptor binding
1.59 1.03e-03 GO:0016563 transcription activator activity
2.54 1.69e-03 GO:0003707 steroid hormone receptor activity
2.40 6.28e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.31 2.25e-02 GO:0042562 hormone binding