Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.121


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_271626880.341.9e-01Click!
HOXB7chr17_-_440432780.087.6e-01Click!
HOXA6chr7_-_271538920.058.5e-01Click!
HOXB6chr17_-_440373320.019.7e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_41579325 13.442


chr7_-_96471544 12.170 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_105511615 10.580 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr8_-_114518194 10.355 NM_052900
NM_198123
 CSMD3

CUB and Sushi multiple domains 3

chr1_-_214963279 8.097 NM_001438
 ESRRG
estrogen-related receptor gamma
chr5_+_170668892 8.003 NM_021025
 TLX3
T-cell leukemia homeobox 3
chr18_-_28606839 7.343 NM_020805
 KLHL14
kelch-like 14 (Drosophila)
chr2_-_200033445 7.078 SATB2
SATB homeobox 2
chr14_+_75907442 6.998 NM_004452
 ESRRB
estrogen-related receptor beta
chr1_-_188713324 6.793 NM_199051
 FAM5C
family with sequence similarity 5, member C
chr10_+_83627422 6.649 NM_001165973
 NRG3
neuregulin 3
chr13_-_45323757 6.531 NM_198849
 SIAH3
seven in absentia homolog 3 (Drosophila)
chr13_-_101852028 6.205 NM_175929
 FGF14
fibroblast growth factor 14
chr18_-_39111243 6.030 NM_020783
 SYT4
synaptotagmin IV
chr14_-_94306104 5.864 NM_173849
 GSC
goosecoid homeobox
chr12_+_79625538 5.766 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr10_+_68355797 5.705 NM_178011
 LRRTM3
leucine rich repeat transmembrane neuronal 3
chr12_-_14024187 5.681 NM_000834
 GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr12_-_23995220 5.552 SOX5
SRY (sex determining region Y)-box 5
chr16_-_49742651 5.506 NM_002968
 SALL1
sal-like 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 133 entries
enrichment   p-value GO term description
4.72 2.78e-03 GO:0048713 regulation of oligodendrocyte differentiation
3.82 1.83e-03 GO:0048665 neuron fate specification
3.07 2.83e-05 GO:0048663 neuron fate commitment
2.97 4.38e-02 GO:0045685 regulation of glial cell differentiation
2.94 2.69e-02 GO:0021515 cell differentiation in spinal cord
2.81 1.11e-02 GO:0001708 cell fate specification
2.74 3.16e-02 GO:0021536 diencephalon development
2.54 1.91e-02 GO:0021510 spinal cord development
2.49 4.80e-05 GO:0021953 central nervous system neuron differentiation
2.34 1.36e-02 GO:0007519 skeletal muscle tissue development
2.30 1.47e-03 GO:0048706 embryonic skeletal system development
2.28 1.79e-02 GO:0060538 skeletal muscle organ development
2.16 3.56e-06 GO:0045165 cell fate commitment
2.16 4.53e-02 GO:0022612 gland morphogenesis
2.10 7.59e-05 GO:0007156 homophilic cell adhesion
2.05 3.71e-03 GO:0043583 ear development
2.05 2.60e-02 GO:0048839 inner ear development
2.01 2.36e-08 GO:0050767 regulation of neurogenesis
1.99 2.72e-06 GO:0045664 regulation of neuron differentiation
1.98 3.66e-09 GO:0051960 regulation of nervous system development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
2.43 1.02e-02 GO:0031093 platelet alpha granule lumen
2.40 5.80e-03 GO:0031983 vesicle lumen
2.38 1.55e-02 GO:0034774 secretory granule lumen
2.33 4.85e-03 GO:0031091 platelet alpha granule
2.28 3.36e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.64 3.49e-02 GO:0030424 axon
1.53 5.60e-04 GO:0043005 neuron projection
1.46 1.37e-02 GO:0009986 cell surface
1.45 1.30e-02 GO:0045202 synapse
1.45 2.11e-02 GO:0031012 extracellular matrix
1.38 5.34e-06 GO:0044421 extracellular region part
1.38 7.05e-03 GO:0030054 cell junction
1.37 4.07e-04 GO:0005615 extracellular space
1.31 7.51e-03 GO:0042995 cell projection
1.26 9.02e-16 GO:0005886 plasma membrane
1.26 6.91e-06 GO:0005576 extracellular region
1.25 8.25e-15 GO:0071944 cell periphery
1.24 1.27e-05 GO:0044459 plasma membrane part
1.10 5.56e-03 GO:0044425 membrane part
1.08 1.21e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
2.54 1.69e-03 GO:0003707 steroid hormone receptor activity
2.40 6.28e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.31 2.25e-02 GO:0042562 hormone binding
1.87 1.38e-21 GO:0043565 sequence-specific DNA binding
1.82 8.15e-05 GO:0000975 regulatory region DNA binding
1.82 8.15e-05 GO:0001067 regulatory region nucleic acid binding
1.82 8.15e-05 GO:0044212 transcription regulatory region DNA binding
1.82 1.71e-04 GO:0010843 promoter binding
1.71 1.97e-07 GO:0004984 olfactory receptor activity
1.68 9.09e-20 GO:0001071 nucleic acid binding transcription factor activity
1.68 9.09e-20 GO:0003700 sequence-specific DNA binding transcription factor activity
1.59 1.03e-03 GO:0016563 transcription activator activity
1.58 1.83e-14 GO:0030528 transcription regulator activity
1.46 4.34e-07 GO:0004930 G-protein coupled receptor activity
1.46 4.32e-05 GO:0005509 calcium ion binding
1.40 2.08e-08 GO:0004888 transmembrane receptor activity
1.37 6.37e-10 GO:0004872 receptor activity
1.32 7.75e-04 GO:0005102 receptor binding
1.30 3.41e-08 GO:0004871 signal transducer activity
1.30 3.41e-08 GO:0060089 molecular transducer activity